The Applied Enzymology Laboratory was established in early 2019 as part of the "SCIENCE" national project. The main requirements for new laboratories were formed at a working meeting with the Deputy Minister of Science and Higher Education of the Russian Federation A.M. Medvedev October 25, 2018:
Thus, the laboratory are aimed at studying enzymes and assessing the prospects for their use in practice. Particular attention is paid to the development of instrumental and methodological base for semi-industrial experiments.The creation of new laboratories should be aimed at the integrated development of research and development in the field of advanced technologies, improving the system of technological transfer of technologies and ensuring the rapid transition of research results to the stage of practical application.
The laboratory actively cooperates with colleagues from other organizations, negotiates with representatives of industry and business in order to build a constructive dialogue on the transfer of technologies from the scientific laboratory to scalable practical applications.
Waste-free recycling
All over the world crabs are a favorite target of fishers due to their high price. The Kamchatka crab is world famous. In recent decades, the volume of the catch of this crab by Russian fishermen has reached 15,000-20,000 tons per year. More than half of the Kamchatka crab catch is waste. On average, such waste can account for 50% of the catch weight, which is often dumped directly into the sea as production waste. The article link
Identification of crab hyaluronidase
Hyaluronidases are a family of enzymes that catalyze the degradation of hyaluronic acid. Hyaluronic acid is a high molecular weight negatively charged polymer, glycosaminoglycan, composed of repeating disaccharide units. Hyaluronidases are used in medicine in combination with other drugs to accelerate the pharmacokinetics and pharmacodynamics of drugs. Mammalian hyaluronidases are used in plastic surgery and dermatology. The manuscript of the article is under development.
Prospects for the use of crab hyaluronidase in medicine
In collaboration with colleagues from other institutes of the Pushchino science city, we were able to demonstrate the structural transformations of hyaluronic acid under the action of enzymes of the king crab hepatopancreas homogenate. Such high-tech methods as atomic force microscopy and nuclear magnetic resonance made it possible to observe the destruction of hyaluronic acid at the molecular level. The article link
